This is the first of a six-part series on how AI is changing medical research and treatments.
The heart in front of me beats and moves like a human organ, but has no blood flowing through it, nor does it live in a human body.
It's a computer-generated heart, or digital twin, used to test implantable cardiovascular devices, like stents, and prosthetic valves that, once confirmed they are safe, will eventually be used on real people.
But the heart's creators, Adsilico, have gone beyond just creating one accurate model.
Using artificial intelligence and huge amounts of data, they have created multiple different hearts.
These AI-generated synthetic hearts can be made to reflect not just biological attributes like weight, age, gender and blood pressure, but health conditions and ethnic backgrounds.
As these differences often aren’t represented in clinical data, digital twin hearts can help device manufacturers conduct trials across more diverse populations than they could with human trials, or trials involving just digital twins without AI.
“This allows us to capture the full diversity of patient anatomies and physiological responses, which is not possible using conventional methods. This use of AI to enhance device testing leads to the development of devices that are more inclusive and safer,” says Adsilico chief executive Sheena Macpherson.In 2018 an investigation by the International Consortium of Investigative Journalists revealed that 83,000 deaths and over 1.7 million injuries were caused by medical devices.
Ms Macpherson hopes that AI powered digital twins can cut down those numbers.
“To really make these devices safer, you need to test them more thoroughly, and it isn't feasible to do that in a clinical trial environment due to the expense of it," says Ms Macpherson, who is based in Northumberland.
"So you want to be able to use the computer-generated version, to make sure that whatever you're doing, you've tested it as thoroughly as possible before you test it on a human.
“Even a fraction of those deaths - and the associated lawsuits - could have been avoided with more thorough testing. You can also get more detailed results.
"You could take the same [virtual] heart and you could test under low or high blood pressure, or against different disease progression, to see whether that affects the device in any way.”
Ms Macpherson adds: “[Virtual] testing gives medical device manufacturers many more insights. It also means that we can test in other sub patient groups, not just white men which clinical trials have traditionally been based on.”Adsilico’s AI models are trained on a combination of cardiovascular data, and data from real MRI and CT scans, that includes medical imaging from consenting patients.
The data draws from detailed anatomical structures of the heart, to help create accurate digital representations of how medical devices will interact with different patient anatomies.
Adsilico’s trials involve the creation of a digital twin of the device to be tested, which is then inserted into the virtual heart in an AI-generated simulation.
It all takes place inside a computer, where the test can be replicated across thousands of other hearts - all AI-simulated versions of a real human heart. Human and animal trials, on the other hand, tend to involve just hundreds of participants.
Perhaps the biggest incentive for drug and device manufacturers to supplement clinical trials with AI digital twins is how it reduces the time it takes, which translates into big cost savings, too.
Drug manufacturer Sanofi, for example, hopes to reduce the testing period by 20%, while also increasing the success rate. It is using digital twin technology in its immunology, oncology and rare disease specialism.
Using biological data from real people, Sanofi creates AI-based simulated patients - not actual clones of specific individuals - that can be interspersed across the control and placebo groups within the trial.
Sanofi’s AI programmes also then creates computer-generated models of the drug to be tested, synthesising properties like how the drug would be absorbed across the body, so it can be tested on the AI patients. The programme predicts their reactions, too - replicating the real trial process.“With a 90% failure rate across the industry of new drugs during clinical development, an increase of just 10% in our success rate by using technologies like digital twins could result in $100m in savings, given the high cost of running late phase clinical trials,” says Matt Truppo, Sanofi’s global head of research platforms and computational research and development.
The results so far have been promising, Mr Truppo, who is based in Boston, US, adds.
“There is still a lot to do. Many of the diseases we are now trying to impact are highly complex. This is where tools like AI come in. Powering the next generation of digital twins with accurate AI models of complex human biology is the next frontier.”Digital twins might have weaknesses though, says Charlie Paterson, an associate partner at PA Consulting and a former NHS service manager.
He points out that the twins are only as good as the data that they are trained on.
"[Due to] aged data collection methods, and low representation of marginalised populations, we could end up in a position where we could still be introducing some of those biases when we're programming virtual recreations of individuals.”
Working with limited legacy data to train its AI is an issue Sanofi is aware of and working to resolve.
To fill gaps in its internal data sets - made up of millions of data points from the thousands of patients that undergo its trials each year - it sources data from third parties, like electronic health records and biobanks.Back at Adsilico, Ms Macpherson is hopeful that one day AI digital twin technology will eliminate animal testing from clinical trials, which is still currently considered an essential part of the drug and device testing process.
“A virtual model of our hearts is still closer to a human heart than that of a dog, cow, sheep, or pig, which tends to be what they use for implantable device studies,” she says.
source : https://www.bbc.com/news/articles/cq8v73dkne3o
President Emmanuel Macron has named centrist leader François Bayrou as France's next prime minister, in a bid to end months of political turmoil.
Bayrou, 73, is a mayor from the southwest and leads the MoDem party. Ahead of the announcement, he spent almost two hours with the president, in talks described as tense by French media.
He is seen by Macron's entourage as a potential consensus candidate and his task will be to avoid the fate of his predecessor. Ex-Brexit negotiator Michel Barnier lasted just three months and was ousted by MPs nine days ago.
Macron is half-way through his second term as president and Bayrou will be his fourth prime minister this year.French politics has been deadlocked ever since Macron called snap parliamentary elections during the summer and an opinion poll for BFMTV on Thursday suggested 61% of French voters were worried by the political situation.
Although a succession of allies lined up to praise Bayrou's appointment, Socialist regional leader Carole Dega said the whole process had become a "bad movie". Far-left France Unbowed leader Manuel Bompard complained of a "pathetic spectacle".
President Macron has vowed to remain in office until his second term ends in 2027, despite Barnier's downfall last week.
He cut short a trip to Poland on Thursday and had been expected to name his new prime minister on Thursday night, but postponed his announcement until Friday.
He then met Bayrou at the Elysée Palace and a final decision was made hours later. But in an indication of the fraught nature of the talks, Le Monde newspaper suggested that Macron had preferred another ally, Roland Lescure, but changed his mind when Bayrou threatened to withdraw his party's support.Bayrou was set to move into the prime minister's residence at Hôtel Matignon within hours, and a red carpet was rolled out for the transfer of power even before his name was confirmed.
His challenge will be in forming a government that will not be brought down the way his predecessor's was in the National Assembly.
Macron has already held round-table talks with leaders from all the main political parties, bar the far-left France Unbowed (LFI) of Jean-Luc Mélenchon and far-right National Rally of Marine Le Pen.
The question will be whether parties from the centre left can be persuaded to join Bayrou's government, or at least agree a pact so they do not oust him.Michel Barnier was only appointed in September and LFI MPs have already indicated they will propose another vote of no confidence in his successor's government.
He was voted out when Le Pen's National Rally joined left-wing MPs in rejecting his plans for €60bn (£50bn) in tax rises and spending cuts. He was seeking to cut France's budget deficit, which is set to hit 6.1% of economic output (GDP) this year.
His outgoing government has put forward a bill to enable the provisions of the 2024 budget to continue into next year. But a replacement budget for 2025 will have to be approved once the next government takes office.
Barnier wished his successor his best wishes in what he called "this serious period for France and Europe".
Under the political system of France's Fifth Republic, the president is elected for five years and then appoints a prime minister whose choice of cabinet is then appointed by the president.
Unusually, President Macron called snap elections for parliament over the summer after poor results in the EU elections in June. The outcome left France in political stalemate, with three large political blocs made up of the left, centre and far right.
Eventually he chose Barnier to form a minority government reliant on Marine Le Pen's National Rally for its survival. Macron is now hoping to restore stability without depending on her party.Three centre-left parties - the Socialists, Greens and Communists - have broken ranks with the more radical left LFI and have taken part in talks on forming a new government.
However, they have made clear they want to see a leftist prime minister of their choice if they are going to join a broad-based government.
"I told you I wanted someone from the left and the Greens and I think Mr Bayrou isn't one or the other," Greens leader Marine Tondelier told French TV on Thursday, adding that she did not see how the centrist camp that lost parliamentary elections could hold the post of prime minister and maintain the same policies.
Sébastien Chenu, a National Rally MP, said for his party it was less about who Macron picked than the "political line" he chose. If Bayrou wanted to tackle immigration and the cost of living crisis then he would "find an ally in us".
Relations between the centre left and the radical LFI of Jean-Luc Mélenchon appear to have broken down over the three parties' decision to pursue talks with President Macron.
After the LFI leader called on his former allies to steer clear of a coalition deal, Olivier Faure of the Socialists told French TV that "the more Mélenchon shouts the less he's heard".
Meanwhile, Marine Le Pen has called for her party's policies on the cost of living to be taken into account by the incoming government, by building a budget that "doesn't cross each party's red lines"
Rev. Andrew, who is the head of St. Andrew's Anglican Church in the United Arab Emirates
In 2011, Thomson published an excellent book entitled 'Christianity in the UAE'.
The book has been used since ancient times throughout the Arab world, including today's United Arab Emirates
Christianity tells.
Archeological information found in the excavation of how Christianity could be lost in the middle
He tries to answer by referring to Then the Christians in the United Arab Emirates today
Analyzes Muslim relations.
Andreas Thomson shouts when he finishes the book
«Where are the bridge -
builders?» Let me listen to their cries and say in my country, "Where is the bridge builder?"
What do you have?" Let me shout.
By tribe and tribe, by creed and creed, by culture and by culture, by party and by party, by opinion and
Between views, Ayale fences have been built in Ethiopia. These fences are of two types
they are. Guardrails and guardrails. It is natural for a living thing to maintain itself.
It is legal and appropriate. For there must be. If a person builds a house for himself, another person should not have a house
He didn't mean it. Just because one person is fed does not mean that the other person is hungry. a person
It does not mean that he controlled and managed his own wealth and property well, but that he stole the wealth of others.
one
A person who takes care of his own health does not mean that he makes others sick. Self and self-identity
Guardrails are important as far as protection goes.
A problem occurs if fences made for protection are converted to protection or from protection
Fences are also being built with retaining walls.
I am the only one. I live
I am alone. He will not marry me for another. I don't know about the other one. That one doesn't concern me. That's his own business.
Over there is my enemy; The fence is made of bricks.
In some villages of our country, people clean their yards.
Good. But the garbage from their yard
They take it out and throw it in an empty place in the village. All the residents of the village cleaned the yard and the village
But it will be dirty. No one can prevent the fly that rises from that pile of garbage to come back and enter his house
No warranty.
We all pass by that pile of garbage. Visitors to all of our homes pass by;
Moreover, all our children play there.
The fence of the village people
It means it is. A fence that kept them from seeing anything about what was going on outside their yard. My yard
Cleansing is very important. But if my neighbor's yard isn't cleaned, it's not worth it. The peace of my home is critical.
But if my neighbor is not at peace, I will be disturbed.
It is commendable that my children are polite.
If my neighbor's children are wild, we have no guarantee that the disease will not spread. Igbo in Nigeria
Tribes have a saying that "it takes every person of the village to raise a child".
And only a fence to connect me and my neighbor, only a map to bring us together, only a greeting to connect us,
Only coffee can bring us together, only tears can make us love, only weddings can make us happy, only Uuta can make us clean.
He can't. We also need a bridge to connect our yard to our neighbor's yard.
The Zulus of South Africa have a strong belief that dates back centuries. When you call it short
They call it "Obuntu". And when he analyzes, he says "Umuntu, Nmuntu, Nmantu". "I am a man
For another reason. My body is connected to you.'' In the belief of Ubuntu
"A person may be happy while others are suffering, and his rights may be respected if others are denied.
Others have failed
He cannot live in peace while others are fighting. What happens to the other
It's thinking that everything will marry me, Ubuntu. They say, "Freedom prevails when we are all free."
Now the country is looking for bridge builders called "Obuntu". From tribe, village, region, faith,
People who can see problems beyond the fence. Cross out what this bean will be like when it grows
Bridge builders who can see.
Bridge builders can bridge their own culture, beliefs, history, environment, language, attitudes, ideologies.
They are the ones who know well and are careful.
Those who don't care about what they have, who love and respect their own
they are. But they have a conscience that goes beyond this. They love, respect, help, understand each other.
They think good for others, do good, and try to respect the rights of others. I need another
They say.
Bridge builders understand reality, not desire. Mutual understanding
They believe in understanding and mutual respect. Know each other, understand each other,
They believe in living by realizing his needs and identity, knowing what he likes and what he hates. "Someone
They understand that every time you are thirsty, you are teaching it to eat you.
There is no change that comes from belittling, belittling and insulting. To honor a person or entity
It doesn't have to be my type. Respect is not acceptance. Respecting the ideology of others
Accepting other's ideology as correct, respecting other's beliefs, correcting other's beliefs
It is not to admit that it is. Respecting others does not come from self-deprecation.
Respect is an expression of peacefulness. Respect is to be respected. Respect is about building rapport.
Superior and inferior, destroyer and destroyer, cannot be reconciled. Communicable respect and
Only when there is equality.
There are historical and contemporary facts: these facts have different meanings for different parties
They may have given in their time.
For example, there are many mosques in the UAE due to historical reasons.
There are many churches in Ethiopia. Amharic is spoken in many places in Ethiopia
have got; African Americans in America have lost their language. The language of Latin America
Lost or exhausted Spanish dominance.
These are historical facts. have become
Respect and consider these facts
It doesn't mean going back and changing. Instead of moving forward and trying to do better. In the Emirates
Churches do not need to be built as much as mosques for Christians to have rights.
But a church for Christians. The number of churches in Ethiopia
It is not when mosques are built that the rights of Muslims are respected.
Adequate places of worship for Muslims
But when they live. When the Oromo language grows, not when the Amharic language slows down, consideration and respect
It is possible.
On the other hand, it is better to look at tomorrow than yesterday to be considered and respected. Until today
Until now, the biggest debate in our country was held yesterday. But tomorrow will bring us closer than yesterday.
It's hard to change yesterday. But tomorrow is in our hands.
The present world gives us the choice of things
It's two. Either we all use as much as we can, or none of us do. Certain
A world where only humans can use it is passing away. Peace comes from the absence of war
She is not. But from mutual benefit. We may not all benefit equally. All of us
But we have to use as much as we can.
This is why we need bridge builders today rather than fence builders. People and people, tribe and
Tribes, believers and believers, parties and parties are fenced in each other, shouting at each other
He sits and stares.
The fences have developed an atmosphere of hostility. The fences brought a sense of protection.
They made everyone think I was being attacked. When the opportunity is available, cross the fence and harass
They are convenient to carry out and hide behind the fence.
These fences kept people from seeing their personal labor and their steel.
"Amhara
He did this, Oromo did this, Tigre did this, Wolayta did this, Islam did this
He did, the Christian did that, the ruling party did that, the opposition did that."
All those in the fences are talked about, accused, blamed.
The hedges became a hiding place.
Bridges are needed to connect these fences. Let's talk, argue, common cause
Let's look for communication bridges that make us live together and respect what separates us
We need them. Respected by those who are beyond this fence and also inside that fence,
We need people who are ashamed. They are the ones who can build bridges.
There is smoke on the other side
Agafari will respond
I went to this party
Overturned from the pony bed
What a beautiful nursery rhyme you sing. The smoke is over there.
It is not the smoke of the enemy; of the enemy
The city is not on fire. They did not say that he was kind to them. It's a party. The feast of the enemy is dead for Tizkar
is not. They are Aghafari. And think that the party that was raised over there is also mine
They're hoping I'll leave that party until I roll over on the bed.
There is no enmity. they
They had built a bridge. But who broke it?
And come, bridge builders.
Connect generation to generation.
Bring tribe to tribe,
Introduce a believer to a believer.
So that we don't end up being divided, so that only resentment and hatred remain for generations, only bad things about each other
So that he doesn't know, there is someone who says he has a relative on the other side, so that he can say, "Agafari will repay"; Over there
However, arguing about these,
There is something to be worried about those who are here
Come, bridge builders!
May this country fail to belong to all of us and not belong to any of us. us and them, this and that,
To build a bridge of "we all" between the fences of here and there,
Come, bridge builders.
Like Noah and Eleazar, one in heaven and the other in hell, "From us to you, and from you to us."
We are saying that there is no way to take it
Come, bridge builders!
Build the bridge so we can all enter heaven together.
In every office, in every neighborhood, in every house, in every taxi, in every media, in every meeting, in every opportunity.
When you see someone who has built a fence, open the closed gate and build a bridge for him. Don't be silent. Holding a fortress
Don't let him live in fear and dread. Build a bridge for him to see if there is another.
Come, bridge builders!
I am in a taxi traveling from Arat Kilo to Mexico City. I am sitting in the second seat on the left side of the passenger seat. As we arrived at the intersection in front of the train station, where traffic jams are often observed, a young woman who was next to me asked if we had arrived at the train station. I asked her if she had arrived at the station without her knowing it, and I pointed out the window on the left side of the taxi, saying, "We have arrived." Without lifting my index finger from the window, I said, "Is there a taxi driver?" in a voice that seemed to be asking not the driver in the taxi we were in, but the taxi driver in the taxi that was turning right and heading towards Churchill Street. We were all shocked by the speed and force of her voice. Especially me... How can I tell you! I thought it was because she spoke to me in a soft and gentle voice at first and I didn't expect such a voice at that place. The assistant, who was resting his left hand full of silver and coins on the front seat backrest and his right hand on the partially open taxi door window, looked like a peppercorn in shock or anger. He turned around and remained silent. The driver, who had just arrived, said, "You can't get off here." The girl stopped talking to the driver and shouted at the assistant, "Open the door for me." The assistant said, "You're kidding me, I won't open it." Whether she heard it or not, he said, "You can get off at Commerce Station." Before he could finish, he said, "Did I tell you I'm going to Commerce Station, not the train station? Turn around!" She struggled to open the door. The driver pulled the taxi over to the right and slowed down, “Why did you hit me again today? You can’t get off at Commerce, can you?” she said in an angry tone. “You have to get off at Commerce, I go to the train station, so I get off at the train station. Why don’t you understand?” She got even angrier. None of the passengers, including me, dared to speak to her. We all looked like we were watching a movie. We watched her when she spoke, the driver when he spoke, and the assistant when he spoke. “If you drop my sister off here, I will sue you! You will sue me,” said the driver, who had not been able to handle the girl. “Who is going to sue you for what I got off at? Don’t I have the right to get off where I want?” She continued to ask questions to the driver, who was confused by her situation. As she said this, although she seemed to be educated by her speech and situation, it was clear that this was not her first time coming to Addis Ababa, and that the sign she had been told to get off at the train station and not pass by!I intervened, assuming that the driver and assistant thought that the place called Commerce Commerce was too far from the train station and that she had little knowledge of road transport laws. The driver and his assistant said nothing to hurt her, that despite the difficulty in expressing themselves, their idea was correct, that the place called Commerce was also close (I showed her through the windshield of the taxi), that the place where she wanted to get off was prohibited by law for taxi passengers to get on or off, and that if necessary, I would get off with her and take her back to the train station. I promised to release the assistant's hand that was holding her shirt and put it down forcibly. Sometimes when I think about it, I feel that there are skills that should not be included in our curriculum but that play a big role in carrying out our daily activities wisely and carefully. For example, basic knowledge about the basic concepts of modes of transportation (air, land, and sea) and their use, as well as national and international laws and regulations, can be provided. We often hear about traffic accidents and the resulting physical disabilities, loss of life and property damage through various information or news outlets. We used to hear such information yesterday and we are still hearing it today. What should we hear tomorrow? Currently, more than 2,000 people lose their lives in traffic accidents in our country every year. More than 8,000 of them suffer serious and minor physical injuries. Property worth more than half a billion birr is destroyed. The reasons often cited as the cause of car accidents are: driver incompetence, poor road conditions, vehicle breakdowns and pedestrian negligence. The key to these reasons is the lack of knowledge. Basic driving knowledge supported by practical experience is needed for the driver, appropriate and quality road construction knowledge and skills for road builders and contractors, knowledge about the main components of the vehicle and their advantages and disadvantages for vehicle owners, and basic road use knowledge for pedestrians. This kind of knowledge is not available overnight. How can a press release issued by the authorities after an accident be used to raise public awareness? Books that provide basic understanding of road use for both drivers and passengers are published by individuals, driver training institutions, and the Road Transport Authority from time to time. The answer is who the user is, who wants to get a driver's license. But pedestrians should also know and be guided by it. Let's take an example of a guideline found in all books based on our country's road system. It states that pedestrians should walk on the left lane on roads open to vehicles. So how effective can this guideline be if only the drivers know it if the pedestrians do not read the book and apply it? The driver knows the law and the system, but the passenger travels by chance or by instinct. Then, as we saw in our introduction, we argue that we are happy or that we should drop off the taxi at the place we want. At other times, we waste time waiting for a taxi by standing in a place where there is no taxi stand and leaning on the tape that prevents taxis from stopping. After all, some taxi drivers do not drive by experience, but by understanding the instructions and road signs in the books. Because they read the book only for the test. If it were not for this, we would not have seen many of our people losing their lives, losing their lives, and destroying their property due to minor mistakes. Some drivers, on the other hand, have combined knowledge with ethics and are proud of their profession. Why did this difference occur? Why is it that the only thing that unites all drivers is the clutch pedal when changing gears? Where did the driver who is forced to wear a seat belt to protect the driver and passenger from accidents and who is punished for this reason come from? Who sent us a driver who does not respect traffic laws unless he sees a traffic policeman? Where did the driver who tries to narrow the difference in the number of passengers between taxis and Anbesa buses by putting a sign in his taxi that says “If there is love, a taxi will also be a bus” come from? At least, those who consider the pedestrian crossing as a tattoo instead of giving priority to pedestrians at the pedestrian crossing, saying that they know the road usage rules better than pedestrians, who drive on roads where there are schools and are crowded, and who lose patience with the endless minutes, who have great goals for themselves, their families, and their country, leave our people behind.Who let the drivers who left us alone? There are also pedestrians who are as likely to get hurt as drivers and cause harm to others and property damage. After all, we all know how to start a fire, we have all been burned at least once. We are told that fire burns, and we believe it, and we protect ourselves from fire. We do not necessarily have to be warned once in advance to protect ourselves from traffic accidents. We do not need a driver's license to know that a car can hit a person, injure a person, and then kill him when he passes by. Just being a human being is more than enough to know this and to consider it. Because we see how even some animals run away when a car comes towards them on the road. How can a person, created in the Trinity, not consider better than an animal, and that is for his own life. But sometimes we are seen as inferior to an animal. There are some roads that are designed to be used in one direction only, but they are used by vehicles coming in both directions. On these roads, they slow down and pass carefully, especially when cars are coming from both directions. No one is expected to tell a pedestrian what precautions he should take on such roads. If he is supposed to walk on the asphalt with the cars, as if he has an oath to not leave the asphalt, if he is injured while struggling to stay on the asphalt, should he say that the car hit him or hit him or even hit him? Have you ever met someone who does not believe or seems to doubt that a car can hit and kill a person? Some of them do not. What should be said about those who are carrying things, carrying children, talking on mobile phones, hugging, holding hands, playing in threes or fours, and who do not step out of the way or do not put out their license plates? Are they following the anti-6 anti-car? There are those who consider crossing the zebra crossing as a guarantee and try to cross the road without caution. I remember reading an article in a taxi that said, “Only a fool who does not learn from his mistakes is a fool.” I do not agree with this article. Because how can a person who has been in a serious accident learn from his mistake by crossing the road without looking left and right, without using the pedestrian crossing, and without taking the necessary precautions? Can he say that he regrets his mistake and undo the damage? In my opinion, most drivers and pedestrians do not lack basic understanding of road transport. What alternative is there to eliminate this lack of awareness in schools, like other forms of education? What if we had a form of education that could provide sufficient information about the types of transportation, the nature of cars, their types, their operation, their use, their management, their marketing, the types of engines with their specifications, the type of tires, the engineering concepts behind each type of transportation, road use guidelines, etc., in a way that focused on the students' ability to think, starting from the first grade? If such education were given from the bottom up, it would also play a major role in attracting students to various engineering professions and instilling a good attitude. It is clear how effective this basic knowledge will be for students who enter various technical and vocational training institutions after completing the 10th grade and how it will help them to do various creative works. Sisters and brothers, do you think we should not include this subject in our curriculum? Please listen to us.He should never be told by another person that he should be careful. If he is supposed to walk on the asphalt, as if he is under oath, and if he is injured while struggling to keep on the asphalt, should he say that the car hit him or that he hit him or that he was hit? Have you ever met someone who does not believe or seems to doubt that a car can hit and kill a person? Some of them do not. Those who are carrying things, holding children, talking on mobile phones, hugging, holding hands, and playing a hot game in three or four groups on a narrow road, what should be said? Are they following the anti-6 anti-car? There are those who consider crossing the zebra crossing as a guarantee and try to cross the road without caution. I remember reading an article in a taxi that said, “Only a fool who does not learn from his mistakes is a fool.” I do not agree with this article. Because how can a person who has been in a serious accident learn from his mistake by crossing the road without looking left and right, without using the pedestrian crossing, and without taking the necessary precautions? Can he say that he regrets his mistake and undo the damage? In my opinion, most drivers and pedestrians do not lack basic understanding of road transport. What alternative is there to eliminate this lack of awareness in schools, like other forms of education? What if we had a form of education that could provide sufficient information about the types of transportation, the nature of cars, their types, their operation, their use, their management, their marketing, the types of engines with their specifications, the type of tires, the engineering concepts behind each type of transportation, road use guidelines, etc., in a way that focused on the students' ability to think, starting from the first grade? If such education were given from the bottom up, it would also play a major role in attracting students to various engineering professions and instilling a good attitude. It is clear how effective this basic knowledge will be for students who enter various technical and vocational training institutions after completing the 10th grade and how it will help them to do various creative works. Sisters and brothers, do you think we should not include this subject in our curriculum? Please listen to us.He should never be told by another person that he should be careful. If he is supposed to walk on the asphalt, as if he is under oath, and if he is injured while struggling to keep on the asphalt, should he say that the car hit him or that he hit him or that he was hit? Have you ever met someone who does not believe or seems to doubt that a car can hit and kill a person? Some of them do not. Those who are carrying things, holding children, talking on mobile phones, hugging, holding hands, and playing a hot game in three or four groups on a narrow road, what should be said? Are they following the anti-6 anti-car? There are those who consider crossing the zebra crossing as a guarantee and try to cross the road without caution. I remember reading an article in a taxi that said, “Only a fool who does not learn from his mistakes is a fool.” I do not agree with this article. Because how can a person who has been in a serious accident learn from his mistake by crossing the road without looking left and right, without using the pedestrian crossing, and without taking the necessary precautions? Can he say that he regrets his mistake and undo the damage? In my opinion, most drivers and pedestrians do not lack basic understanding of road transport. What alternative is there to eliminate this lack of awareness in schools, like other forms of education? What if we had a form of education that could provide sufficient information about the types of transportation, the nature of cars, their types, their operation, their use, their management, their marketing, the types of engines with their specifications, the type of tires, the engineering concepts behind each type of transportation, road use guidelines, etc., in a way that focused on the students' ability to think, starting from the first grade? If such education were given from the bottom up, it would play a major role in attracting students to various engineering professions and instilling a good attitude. It is clear how effective this basic knowledge will be for students who enter various technical and vocational training institutions after completing the 10th grade and how it will help them to do various creative works. Sisters and brothers, do you think we should not include this subject in our curriculum? Please listen to us.Do you think we shouldn't include this subject in our curriculum? Please let us know.Do you think we shouldn't include this subject in our curriculum? Please let us know.
Develop the lamb's mind
There was an individual who was selling red, yellow, blue and green balloons with other colors at a reasonable price for children. When the business is cold, the man fills a balloon with helium gas and releases it into the sky. When the children see this, they come to him and buy him, eager to have something similar. Then the market will come back hot, hot.
One day, the balloon seller felt his clothes being pulled from behind, and when he turned around, a baby boy standing behind him asked, "Can a black balloon float in the air like the others?" It's something," he explained. The owner's answer has a prominent role in our lives. It is not our outward appearance that makes us go uphill or down, but our inner attitude. William James of Harvard University once said, "The greatest discovery of this generation is that human beings can change their lives simply by changing the way they think." The big role that we play in our success
According to a study conducted by Harvard University, 85% of the main reason people hold back on a new job or promotion is their attitude.
The remaining 15 percent depends on their skills and reputation. What is surprising is that our entire educational expenditure and our total energy is wasted on only this fifteen percent of professional and intellectual skills.
However, our victory and success are completely determined by this eighty-five percent attitude. Attitude is a key word. The role it plays in everyone's professional and personal life is significant. A good attitude of an official
What would be a good manager if he didn't have one? How can a student be a successful student without optimism? How can teachers, parents, sales staff, employers and employees do their jobs properly and be successful without a good attitude?
No matter what field of work you are engaged in; The only basis of your success is your success
So, since your attitude is so important to your successful life, wouldn't you be eager to examine your attitude from the present moment and examine how it can help you reach your goals?
He is a thug living in Africa who is happy with what he has. He who is happy is satisfied with what he has. His contentment with what he had was derived from this happiness. One day a wise man came to him and told him how much power collecting diamonds could give him. “If you have a diamond the size of your thumb, you can buy the city you live in. And if you have a diamond the size of your hand, you can buy the whole country!” He explained to him.
Hafez did not sleep well that night after the wise man left him. For the first time, a feeling of unhappiness swept over him. He was unhappy because he was not satisfied with what he had. He couldn't be satisfied with what he had if he wasn't happy.
The next day, Hafez made arrangements to sell his farm and after packing his family's belongings, he prepared to travel in search of the diamonds. Although the expedition covered the whole of Africa, he could not find a single particle of diamond.
The result of his extensive exploration across Europe was the same. When he arrived in Spain, his body was shaken, his mind was confused, and his spirit was broken. Apart from this, he was severely short of funds. Therefore, what seemed like a solution to get rid of his anxiety was to commit suicide by throwing himself into the Barcelona river. And he did it in practice, and when they heard him, he fell asleep.
The man who bought Hafez's farm one day while he was watering the camels from the river that runs through his farm, he found a shiny stone and took it to my house and grabbed it, thinking that it could be a decoration that he kept from the reception.
That afternoon, my wise man came to him. And he saw the stone shining. "Has Hafez returned?" he asked. "No, he has not returned, but why did you ask me?"
“Because this stone you see is a diamond. I talked to Hafez about this.'' "So this is it, I brought this stone from the river and put it here," explained the farmer. "Come, let me show you, there are others," invited the wise man. On the same day, after picking up many similar stones, they sent some of them to an expert. As a result, they all turned out to be diamonds. It was also discovered that the area of Farm is rich in diamond wealth.
What is the point of this story?
Six main points can be made:
1. Our attitude is positive and correct
if so; Each of us We understand that we are walking in a land rich in diamond wealth. Opportunity is always at our feet. We don't have to go anywhere to find her. All we have to do is wake up to realize this opportunity.
2. Grass is green no matter which way we look at it.
3. While we are looking at the grass on one side, let us notice that there are others who see on the other side and perhaps these people may have a strong desire to take our place and pour wealth from our door.
4. Unlucky to realize a good opportunity People scream when good luck knocks on their door, and they get upset because the past triggers their negative emotions.
5. May good opportunities and opportunities slip away from us But the chances of us realizing that they are knocking on our door are very small.
6. Luck knocks on our door only once. The next time may be better or worse. This is where we have to make the right decision at the right time. The right decision at the wrong time becomes the wrong decision.
Who invented cement and when was cement invented? The history of cement is fascinating, but it is important to establish from the outset that cement and concrete are different substances entirely. Despite people colloquially referring to these words as synonymous, concrete is the hard substance that makes up many buildings and sidewalks, and cement is the binding agent inside of it.
Joseph Aspdin (25 December 1778 – 20 March 1855) was an English bricklayer, businessman, inventor, and stonemason who obtained the patent for Portland cement on 21 October 1824.
Joseph Aspdin applied for a patent on this material he invented in his kitchen. He received it in 1824 with the patent number BP 5022. He named his new material Portland Cement. Portland Stone was quarried in England and had very high repute for being strong, high quality, and beautiful. The color of cement was similar to Portland Stone once it was cured and dried. Aspdin thought that naming his invention after something so reputable would help his business thrive, and he was right. He partnered in business with his neighbor, William Beverley. While his business selling Portland Cement was successful at the time, his invention wasn't as hugely widespread during his lifetime as it is in the modern world. Joseph Aspdin seemed to think this new material would be most useful as a beautiful facade for homes and other buildings. However, the material is now used as the primary building block of construction, ranging from highways and roads to buildings and monuments. His original formula was modified by his son, William Aspdin, into the final form used today.
Reference
https://en.wikipedia.org/wiki/Joseph_Aspdin
https://study.com/learn/lesson/joseph-apsdin-history-invention-cement.html
An 8-¬‐year-¬‐old girl went to her dad, who was working in the yard. She asked him, "Daddy, what is sex?" The father was surprised that she would ask such a question, but decides that if she is old enough to ask the question, then she is old enough to get a straight answer. He proceeded to tell her all about the 'birds and the bees'. When he finished explaining, the little girl was looking at him with her mouth hanging open. The father asked her, "Why did you ask this question?" The little girl replied, "Mom told me to tell you that dinner would be ready in just a couple of secs."
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A grad student, a post--‐doc, and a professor are walking through a city park and they
find an antique oil lamp. They rub it and a Genie comes out in a puff of smoke.
The Genie says, "I usually only grant three wishes, so I'll give each of you just one."
"Me first! Me first!" says the grad student. "I want to be in the Bahamas, driving a speedboat
with a gorgeous woman who sunbathes topless." Poof! He's gone.
"Me next! Me next!" says the post--‐doc. "I want to be in Hawaii, relaxing on the beach with a
professional hula dancer on one side and a Mai Tai on the other." Poof! He's gone.
"You're next," the Genie says to the professor.
The professor says, "I want those guys back in the lab after lunch."
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Before you criticize someone, walk a mile in their shoes. Then when you do criticize
them, you'll be a mile away and have their shoes.
Could this egg-shaped structure be what the future home of Indian astronauts in space looks like?
The Hab-1 - short for Habitat-1 – is Indian space agency Isro's first-ever "analog mission" which means simulation of space conditions to prepare astronauts for real space missions. It was recently tested for three weeks in the high Himalayan mountains of Ladakh.
Space architect Aastha Kacha-Jhala, from Gujarat-based firm Aaka, told the BBC that these simulations help identify and address issues astronauts and equipment might face before space missions.
Built with space-grade Teflon and insulated with industrial-use foam, Hab-1 has a bed, a stowaway tray which can be pulled out and used as a workstation, storage space to keep supplies and emergency kits, a kitchenette for heating meals and a toilet. An astronaut in simulation spent three weeks holed up in the facility.
"Hab-1 is designed keeping in mind that space is going to be very limited on the Moon or Mars," Ms Kacha-Jhala says. "The astronaut will also have very limited water so we designed a dry toilet. We also put in place a system for a proper disposal of waste and ensured that the habitat remained odour-free."
She is now in talks with Isro to build India's first permanent simulation space facility in Ladakh.
The mission comes at a time when India is preparing to send its first astronauts into space.
Isro's Gaganyaan mission plans to place three astronauts into low-Earth orbit at an altitude of 400km (248 miles) for three days. If all goes according to plan, the mission will launch sometime next year. India also plans to set up its first space station by 2035 and send a man to the Moon by 2040.
Nasa, European Space Agency, Russia, China and other countries and private firms with space programmes run dozens of simulation missions and two of the four Indian astronauts selected for the Gaganyaan mission are being trained at Nasa at the moment.
"Once we have our own simulation mission, we won't have to depend on foreign space agencies to train our astronauts," says Prof Subrat Sharma, Dean of Research Studies at Ladakh University which collaborated on the project.Ladakh, he told the BBC, was chosen for the experiment because "from a geographical perspective, its rocky, barren landscape and soil have similarities with the material and rocks found on Mars and some parts of the lunar terrain which make it ideal for space research".
The soil samples collected during the mission are being tested by the university to see if astronauts will be able to use locally-sourced materials to build homes in space.The Himalayan region on the India-China border is located at a height of 3,500 metres (11,483ft) and has extreme climatic conditions and thin air. In a day, the temperature here can shift from a maximum of 20C to a minimum of -18C.
It's no match for Mars (where temperatures can go below -153C) or Moon (where -250C is the norm in some deep craters), but still, it's a test of human endurance. And as Prof Sharma says, "since you can't go to space to test every time, you need these facilities where space-like conditions can be created".
Also, he adds, Ladakh is one region of India where barren land stretches for miles and miles, "giving you the feeling of being alone on the planet".
And that's exactly how the simulation astronaut, who spent three weeks confined in the capsule in the icy cold desert, felt.
Chandrayaan-3: India makes historic landing near Moon's south pole
"I was isolated from the human environment. Every move that I made was scheduled, when to wake up, what to do when and when to sleep? A 24x7 camera monitored every move and sent data about my activities and health to the back office," the 24-year-old who did not want to be named told me.
"The initial few days," he said, "were great, but then it began to feel repetitive and it started to get to me. It started impacting my daily performance. My sleep schedule was affected a little and my concentration deteriorated."
The simulation astronaut wore biometric devices to monitor his sleep pattern, heart rate and stress levels. His blood and saliva were tested daily to see how he was coping.Scientists say simulating psychological factors to see how they would impact humans in space is one of the most important parts of the mission.
With space agencies from across the world aiming to send astronauts to the Moon and set up permanent bases there in the coming years, simulation missions are expected to play a crucial role in research and training.n April, a team of scientists and engineers began trials in Oregon to prepare Nasa's robot dog – Lassie – to walk on the Moon's surface. In July, four volunteers emerged after spending a year at an "analog" facility, specially built in Texas to simulate life on Mars.
And according to the Economist magazine, Nasa hopes to 3D-print a base using only materials found on the Moon's surface, while China and Russia are collaborating on their own plans.
India doesn't want to be left behind. Prof Sharma says once the data gathered in Ladakh is analysed, it "will help us develop medical technology to deal with the needs of our astronauts when they face a problem in space".
"We need to know how our bodies will function on the Moon where days and nights are a lot longer than on Earth. Or in space where there's not enough oxygen" he says.